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1.
Obes Surg ; 2024 Apr 23.
Artículo en Inglés | MEDLINE | ID: mdl-38652437

RESUMEN

Laparoscopic Roux-en-Y gastric bypass (RYGB) is crucial for significant weight reduction and treating obesity-related issues. However, the impact of gastrojejunostomy (GJ) anastomosis diameter on weight loss remains unclear. We investigate this influence on post-RYGB weight loss outcomes. A systematic search was conducted. Six studies met the inclusion criteria, showing varied GJ diameters and follow-up durations (1-5 years). Smaller GJ diameters generally correlated with greater short-to-medium-term weight loss, with a threshold beyond which complications like stenosis increased. Studies had moderate-to-low bias risk, emphasizing the need for precise GJ area quantification post-operation. This review highlights a negative association between smaller GJ diameters and post-RYGB weight loss, advocating for standardized measurement techniques. Future research should explore intra-operative and AI-driven methods for optimizing GJ diameter determination.

2.
Materials (Basel) ; 17(3)2024 Jan 28.
Artículo en Inglés | MEDLINE | ID: mdl-38592004

RESUMEN

In order to determine the ideal degree of inclination that should be employed for constructing effective thermal energy storage systems, it is important to examine the impact of inclination angle on the melting behavior of phase change materials (PCMs) such as paraffin wax within a square cell. In consequence, this would guarantee the greatest capacity for energy release and storage. Additionally, analyzing this influence aids engineers in creating systems that enhance heat flow from external sources to the PCM and vice versa. To find out how the cell's inclination angle affects the melting of PCM of paraffin wax (RT42) inside a square cell, a numerical analysis is carried out using the ANSYS/FLUENT 16 software. Specifically, the temperature and velocity distributions, together with the evolution of the melting process, will be shown for various inclination angles, and a thorough comparison will be made to assess the influence of inclination angle on the PCM melting process and its completion. The findings demonstrated that when the cell's inclination angle increased from 0° to 15° and from 0° to 30° and 45°, respectively, the amount of time required to finish the melting process increased by 15%, 42%, and 71%, respectively. Additionally, after 210 min of operation, the PCM's maximum temperature is 351.5 K with a 0° angle of inclination (horizontal) against 332.5 K with an angle of inclination of 45°.

3.
Sci Rep ; 14(1): 6148, 2024 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-38480813

RESUMEN

This study aims to investigate the effects of introducing a 50/50 mixture of silica and magnesium oxide nanoparticles (SNP + MgONP) to the viscosity of Al-Ahdab crude oil (Iraq) at varied concentrations and temperatures. It is observed that the viscosity value drops from 38.49 to 7.8 cP. The highest degree of viscosity reduction is measured to be 56.91% at the maximum temperature of 50 °C and the greatest concentration of 0.4 wt% SM4. The Bingham model can be used to classify the behavior of the crude oil before the Nano-mixture is added. The liquid behavior grew closer to Newtonian behavior once the Nano-mixture was added. Along with a rise in plastic and effective viscosity values, the yield stress value decreases as the concentration of the Nano-mixture increases. The numerical data demonstrate that when the volume proportion of nanoparticles increases, the pressure distribution decreases. Furthermore, as the nanoparticle volume fraction increases, the drag decrease would also increase. SM4 obtains a maximum drag reduction of 53.17%. It is discovered that the sample SM4 has a maximum flow rate increase of 2.408%. Because they reduce the viscosity of crude oil, nanoparticles also reduce the friction factor ratio.

4.
Obes Surg ; 34(3): 967-975, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38240941

RESUMEN

The aim of this meta-analysis was to compare the effects of LRYGB and LSG on dyslipidemia. Studies comparing the effects of LRYGB and LSG on dyslipidemia with follow-up of 12 months or more were included. Twenty-four studies comprising seven RCTs and 17 comparative observational studies were included. Meta-analysis of RCTs (n=487) showed that improvement/resolution of dyslipidemia was better after LRYGB (68.5%, n=161/235) compared to LSG (48.4%, n=122/252). Patients undergoing LRYGB were more than twice as likely to experience improvement/resolution in dyslipidemia compared to those undergoing LSG (OR 2.28, 95% CI 1.21-4.29, p=0.010). Both LRGYB and LSG appears effective in improving dyslipidemia at >12 months after surgery; however, this improvement is more than twice higher after LRYGB compared to LSG.


Asunto(s)
Dislipidemias , Derivación Gástrica , Laparoscopía , Obesidad Mórbida , Humanos , Obesidad Mórbida/cirugía , Gastrectomía , Dislipidemias/cirugía , Resultado del Tratamiento
5.
Surg Obes Relat Dis ; 20(5): 446-452, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38218689

RESUMEN

BACKGROUND: Enhanced Recovery After Surgery (ERAS) programs have been widely adopted in bariatric surgery. However, not all patients are successfully managed in the ERAS setting and there is currently little way of predicting the patients who will deviate from the program. Early identification of these patients could allow for more tailored protocols to be implemented preoperatively to address the issues, thereby improving patient outcomes. OBJECTIVES: The aim of this study was to elucidate the factors which preclude discharge by comparing patients who were successfully discharged by the end of the first postoperative day (POD 0/1) to those who stayed longer, including revisional surgery in this analysis. SETTING: A tertiary, high-volume Bariatric Centre, United Kingdom. METHODS: A retrospective analysis was performed of all patients undergoing bariatric surgery in a single centre in 1 year. Multivariate analyses compared patient and operative variables between patients who were discharged on POD 0/1 and those who stayed longer. RESULTS: A total of 288 bariatric operations were performed: 78% of operations performed were laparoscopic Roux-en-Y gastric bypass; 22% laparoscopic sleeve gastrectomy. Of these cases, 13% were revisional operations. Four patients returned to theatre on the index admission. 81% of patients were discharged by POD 0/1. A re-presentation within 30 days was seen in 6% of patients. There was no significant difference in length of stay for the type of operation performed (P = .86). Patients who had a revisional procedure were not more likely to stay longer. Length of stay was also independent of age, BMI, and comorbidities. Caucasian patients were more likely to be discharged on POD 0/1 than those of other ethnicities (90% versus 78%; P = .02). Operations performed by trainee surgeons, under consultant supervision, were significantly more likely to be discharged on POD 0/1 (P = .03). However, a logistic regression analysis was unable to predict patients who had a prolonged stay. CONCLUSIONS: Patient length of stay is independent of BMI, operation, and comorbidities and these factors do not need special consideration in ERAS pathways. Patients undergoing revisional procedures can be managed in the same way as those having primary procedures, with a routine POD 0/1 discharge. However, the impact of individual patient factors, and their interaction, is complex and cannot predict overstay.


Asunto(s)
Cirugía Bariátrica , Recuperación Mejorada Después de la Cirugía , Tiempo de Internación , Obesidad Mórbida , Alta del Paciente , Humanos , Estudios Retrospectivos , Femenino , Masculino , Cirugía Bariátrica/estadística & datos numéricos , Cirugía Bariátrica/métodos , Alta del Paciente/estadística & datos numéricos , Adulto , Obesidad Mórbida/cirugía , Tiempo de Internación/estadística & datos numéricos , Persona de Mediana Edad , Reoperación/estadística & datos numéricos
6.
Sci Rep ; 13(1): 21140, 2023 Nov 30.
Artículo en Inglés | MEDLINE | ID: mdl-38036570

RESUMEN

Hybrid nanofluids offer higher stability, synergistic effects, and better heat transfer compared to simple nanofluids. Their higher thermal conductivity, lower viscosity, and interaction with magnetic fields make them ideal for various applications, including materials science, transportation, medical technology, energy, and fundamental physics. The governing partial differential equations are numerically solved by employing a finite volume approach, and the effects of various parameters on the nanofluid flow and thermal characteristics are systematically examined from the simulations based on a self-developed MATLAB code. The parameters included magnetic field strength, the Reynolds number, the nanoparticle volume fraction, and the number and position of the strips in which the magnetic field is localized. It has been noted that the magnetized field induces the spinning of the tri-hybrid nanoparticles, which generates the intricate structure of vortices in the flow. The local skin friction (CfRe) and the Nusselt number (Nu) increase significantly when the magnetic field is intensified. Moreover, adding more nanoparticles in the flow enhances both Nu and CfRe, but with different effects for different nanoparticles. Silver (Ag) shows the highest increase in both Nu (52%) and CfRe (110%), indicating strong thermal-fluid coupling. Alumina (Al2O3) and Titanium Dioxide (TiO2) show lower increases in both Nu (43% and 34%) and CfRe (14% and 10%), indicating weaker coupling in the flow. Finally, compared with the localized one, the uniform magnetic field has a minor effect on the flow and temperature distributions.

7.
Cureus ; 15(9): e46017, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37900497

RESUMEN

Traumatic diaphragmatic hernias (TDHs) can occur after both blunt and penetrating injury. Laparotomy and thoracotomy are commonly done for the management of TDHs. Minimally invasive surgery, especially laparoscopic surgery, is being accepted as an effective and safe alternative to open surgical repair even in trauma cases. Laparoscopy also allows for the detection and management of clinically occult TDHs, thereby preventing the complications of missed or delayed diagnosis. Our case highlights the importance of timely intervention with a minimally invasive approach. A 39-year-old male presented to the emergency room after a road traffic accident. Computed tomography scan confirmed left-sided diaphragmatic rupture with gastric herniation. Laparoscopic repair of the hernia was done. He had an uneventful post-operative period. At the one-year follow-up, he was asymptomatic and was doing well. TDHs have a variable clinical presentation and radiological findings are not always diagnostic. Such cases can progress to potentially life-threatening complications such as strangulation and perforation of the herniated viscera. Timely diagnosis and management are therefore essential. A minimally invasive approach such as laparoscopy should be used for the management of TDHs in the acute setting where the patient is stable, and resources are available. In this case, once the gastric contents were aspirated via a nasogastric tube in the middle of the night, the immediate need for surgery was converted to an urgent nature, and the patient underwent surgery the next morning in a more controlled setting. In addition, timely intervention can prevent future complications that may occur if the condition is left untreated during the initial admission.

8.
Clin Med (Lond) ; 23(4): 330-336, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-37524428

RESUMEN

Obesity has reached pandemic levels globally. Surgical management of obesity aims to establish metabolic control, weight loss and resolution of multiple health conditions and to improve quality of life. Here, we examine the role of surgery in the management of obesity within the context of a multidisciplinary team involving a variety of healthcare professionals. We highlight the importance of patient selection, perioperative care, the various types of bariatric surgery currently available as well as emerging procedures. In addition to clarifying the different types of procedure, we also examine the potential complications and issues of weight regain and failure to lose weight. Ultimately, bariatric surgery remains comparatively safe and with generally excellent results in terms of control of existing obesity-related conditions; with the ever-increasing number of patients living with obesity, the scope of bariatric surgery is thus likely to increase.


Asunto(s)
Cirugía Bariátrica , Obesidad Mórbida , Humanos , Calidad de Vida , Estudios Transversales , Multimorbilidad , Obesidad/complicaciones , Obesidad/cirugía , Cirugía Bariátrica/métodos
9.
Am Surg ; 89(11): 4406-4412, 2023 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-35818960

RESUMEN

BACKGROUND: Recent evidence has emerged reporting atypical clinical symptoms of the novel coronavirus (COVID-19). There is a sparsity of existing studies examining COVID-19-related abdominal pain and the role of investigative imaging for the virus in these patients. Study aims were to determine COVID-19 incidence in those with acute abdominal pain in the absence of respiratory symptoms and to assess the diagnostic performance of CT thoracic imaging in such patients. METHODS: Retrospective analysis of all consecutive patients admitted to our emergency general surgical unit between 1st March 2020 and 31st May 2020 was performed. In adherence with national guidelines, all patients underwent nasal and oro-pharyngeal COVID-19 RT-PCR swabs as well as thoracic and abdominal computed tomography (CT) on admission. RESULTS: From 112 patients admitted with acute abdominal pain in the absence of respiratory symptoms, 16 (14.3%) tested positive for COVID-19 on RT-PCR swab testing. Overall, 50% (8/16) of these patients had no intra-abdominal pathology on CT. The sensitivity and specificity of CT thoracic imaging for diagnosing COVID-19 was 43.8% and 91.7%, respectively. Patients with positive COVID-19 swabs had higher C-reactive protein levels, lower potassium levels and a higher proportion of those with a low lymphocyte count. DISCUSSION: One in seven patients with abdominal pain without any respiratory symptoms tested positive for COVID-19. Half of these patients represented COVID-19 manifesting primarily as acute abdominal pain. Combined swab testing and CT imaging should be performed in all abdominal pain presentations due to the varying diagnostic performance of thoracic CT in diagnosing COVID-19.


Asunto(s)
Abdomen Agudo , COVID-19 , Humanos , COVID-19/epidemiología , Prueba de COVID-19/métodos , Estudios Retrospectivos , Dolor Abdominal/diagnóstico , Dolor Abdominal/etiología , Abdomen Agudo/etiología , Abdomen Agudo/complicaciones , Reino Unido/epidemiología
10.
Nanomaterials (Basel) ; 12(14)2022 Jul 19.
Artículo en Inglés | MEDLINE | ID: mdl-35889705

RESUMEN

Many strategies have been attempted for accomplishing the needed changes in the heat-transfer rate in closed cavities in recent years. Some strategies used include the addition of flexible or hard partitions to the cavities (to split them into various pieces), thickening the borders, providing fins to the cavities, or altering the forms or cavity angles. Each of these methods may be used to increase or decrease heat transmission. Many computational and experimental investigations of heat transport in various cavity shapes have been conducted. The majority of studies focused on improving the thermal efficiency of heat transmission in various cavity containers. This paper introduced a review of experimental, numerical, and analytical studies related to heat transfer analyses in different geometries, such as circular, cylindrical, hexagonal, and rectangular cavities. Results of the evaluated studies indicate that the fin design increased heat transmission and sped up the melting time of the PCM; the optimal wind incidence angle for the maximum loss of combined convective heat depends on the tilt angle of the cavity and wind speed. The Nusselt number graphs behave differently when decreasing the Richardson number. Comparatively, the natural heat transfer process dominates at Ri = 10, but lid motion is absent at Ri = 1. For a given Ri and Pr, the cavity without a block performed better than the cavity with a square or circular block. The heat transfer coefficient at the heating sources has been established as a performance indicator. Hot source fins improve heat transmission and reduce gallium melting time.

11.
Obes Surg ; 31(8): 3462-3467, 2021 08.
Artículo en Inglés | MEDLINE | ID: mdl-33881739

RESUMEN

The laparoscopic approach for dealing with bariatric complications has become the gold standard of modern practice. The aim of this study is to assess the role of relaparoscopy as a diagnostic and therapeutic approach towards managing complications and improving 30-day outcome. MATERIALS AND METHODS: A retrospective review of a prospectively maintained database was conducted in a tertiary bariatric unit. Data were collected on all bariatric surgical procedures performed between March 2013 and March 2019. Any patient who was returned to theatre for a suspected serious complication was identified and their outcome studied. RESULTS: Over the 5-year study period, the total number of operations performed was 1660 (981 laparoscopic gastric bypass (LRYGB), 612 laparoscopic sleeve gastrectomy (LSG) and 67 revisional bariatric operations). Early postoperative complications (in hospital or within 30 days of surgery) that lead to reoperation were recorded in 33 patients (1.9%). These complications occurred after LRYGB in 26 patients (2.65%) and LSG in 7 patients (1.14%), respectively. Anastomotic leaks occurred in 1.1% of LRYGB, whilst 0.6% of patients have jejuno-jejunostomy obstruction. Obstruction at the gastro-jejunostomy anastomosis occurred in one patient. Following LSG, one mortality was recorded following bleeding from the staple line (0.06%) and five patients (0.3%) had leaks from the staple line. Thirty-one reoperations were performed laparoscopically, and two were converted to the open approach, whilst 2 operations were planned as open from the outset. CONCLUSION: Relaparoscopy is an effective and safe approach to the management of clinically or radiologically suspected early complications after bariatric surgery. Graphical abstract.


Asunto(s)
Cirugía Bariátrica , Derivación Gástrica , Gastroplastia , Laparoscopía , Obesidad Mórbida , Cirugía Bariátrica/efectos adversos , Gastrectomía/efectos adversos , Derivación Gástrica/efectos adversos , Humanos , Obesidad Mórbida/cirugía , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/cirugía , Reoperación , Estudios Retrospectivos , Resultado del Tratamiento
12.
Postgrad Med J ; 97(1144): 110-116, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32788312

RESUMEN

SARS-CoV-2 is a virus that is the cause of a serious life-threatening disease known as COVID-19. It was first noted to have occurred in Wuhan, China in November 2019 and the WHO reported the first case on December 31, 2019. The outbreak was declared a global pandemic on March 11, 2020 and by May 30, 2020, a total of 5 899 866 positive cases were registered including 364 891 deaths. SARS-CoV-2 primarily targets the lung and enters the body through ACE2 receptors. Typical symptoms of COVID-19 include fever, cough, shortness of breath and fatigue, yet some atypical symptoms like loss of smell and taste have also been described. 20% require hospital admission due to severe disease, a third of whom need intensive support. Treatment is primarily supportive, however, prognosis is dismal in those who need invasive ventilation. Trials are ongoing to discover effective vaccines and drugs to combat the disease. Preventive strategies aim at reducing the transmission of disease by contact tracing, washing of hands, use of face masks and government-led lockdown of unnecessary activities to reduce the risk of transmission.


Asunto(s)
COVID-19 , SARS-CoV-2 , COVID-19/diagnóstico , COVID-19/epidemiología , COVID-19/terapia , Humanos
13.
Obes Surg ; 30(10): 3968-3973, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-32524523

RESUMEN

INTRODUCTION: Literature on long-term (> 10 years) outcomes in terms of weight loss, resolution of co-morbidities, and quality of life (QoL) after bariatric surgery is limited. The aim of this study was to investigate the excess weight loss (EWL), resolution of comorbidities, and QoL more than 10 years after laparoscopic Roux-en-Y gastric bypass (LRYGB) using the Bariatric Analysis and Reporting Outcome System (BAROS). METHODS: Data on patient demographics, weight, body mass index (BMI), comorbidities, type of surgery, complications, and QoL were collected from a prospectively maintained database. RESULTS: A total of 92 patients out of 104 who underwent LRYGB during the study period and completed a median follow-up of 130 months were successfully contacted. The median age was 48 years (IQR 42-54 years) and 85.9% had a BMI of more than 40. The median excess weight loss (EWL) was 46.5% (IQR 27.9-64.3%). Type 2 diabetes mellitus reduced from 56.5 to 23.9% (p < 0.001), hypertension from 51.1 to 39.1% (p = 0.016), and obstructive sleep apnoea from 33.7 to 12.0% (p < 0.001). Participants reported feeling better (median 0.2, IQR 0.2-0.4), engaging in more physical activity (0.1, IQR 0.1-0.3), having more satisfactory social contacts (0.4, IQR 0.2-0.5), a better ability to work (0.3, IQR - 0.1-0.5), and a healthier approach to food (0.2, IQR - 0.3-0.3) at the end of follow-up. CONCLUSION: LRYGB leads to positive outcomes in terms of weight loss, reduction in comorbidities, and improvement in QoL at a follow-up of more than 10 years.


Asunto(s)
Diabetes Mellitus Tipo 2 , Derivación Gástrica , Laparoscopía , Obesidad Mórbida , Índice de Masa Corporal , Diabetes Mellitus Tipo 2/epidemiología , Humanos , Persona de Mediana Edad , Obesidad Mórbida/cirugía , Calidad de Vida , Estudios Retrospectivos , Resultado del Tratamiento
14.
Obes Surg ; 29(11): 3712-3721, 2019 11.
Artículo en Inglés | MEDLINE | ID: mdl-31309524

RESUMEN

BACKGROUND: Obesity is associated with a twofold risk of gastroesophageal reflux disease (GERD) and thrice the risk of Barrett's esophagus (BE). Roux-en-Y gastric bypass (RYGB) leads to weight loss and improvement of GERD in population with obesity, but its effect on BE is less clear. METHODS: Bibliographic databases were searched systematically for relevant articles till January 31, 2019. Studies evaluating the effect of RYGB on BE with preoperative and postoperative endoscopy and biopsy were included. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) tool. Meta-analysis was conducted using Mantel-Haenszel, random effects model and presented as risk difference (RD) or odds ratio (OR) with 95% confidence intervals. RESULTS: Eight studies with 10,779 patients undergoing RYGB reported on 117 patients with BE with follow-up of > 1 year. Significant regression of BE after RYGB was observed (RD - 0.56.95% c.i. - 0.69 to - 0.43; P < 0.001). Subgroup analysis showed regression of both short-segment BE [ssBE] (RD - 0.51.95% c.i. - 0.68 to - 0.33; P < 0.001) and long-segment BE [lsBE] (RD - 0.46.95% c.i. - 0.71 to - 0.21; P < 0.001). RYGB also caused improvement in GERD in patients of BE (RD - 0.93, 95% c.i. - 1.04 to - 0.81; P < 0.001). RYGB was strongly associated with regression of BE compared with progression (OR 31.2.95% c.i. 11.37 to 85.63; P < 0.001). CONCLUSIONS: RYGB leads to significant improvement of BE at > 1 year after surgery in terms of regression and resolution of the associated GERD. Both ssBE and lsBE improve after RYGB significantly.


Asunto(s)
Esófago de Barrett , Derivación Gástrica/estadística & datos numéricos , Obesidad , Esófago de Barrett/complicaciones , Esófago de Barrett/epidemiología , Esófago de Barrett/patología , Humanos , Obesidad/complicaciones , Obesidad/cirugía
15.
Surg Obes Relat Dis ; 15(9): 1620-1631, 2019 09.
Artículo en Inglés | MEDLINE | ID: mdl-31358394

RESUMEN

BACKGROUND: Obesity leads to impairment of physical activity as measured by an inability to perform activities of daily living. Literature on the effect of bariatric surgery on physical activity is conflicting. OBJECTIVE: The aim of this study was to perform a meta-analysis of the effect of bariatric surgery on physical activity from studies employing objective measurement and self-reporting of physical activity before and after bariatric surgery. METHODS: Bibliographic databases were searched systematically for relevant literature until December 31, 2018. Studies employing objective and self-reported measurement of physical activity were included. Study quality was assessed using Risk of Bias in Nonrandomized Studies - of Interventions tool. Meta-analysis was performed using random effects model and presented as standardized mean difference (SMD) with 95% confidence intervals (CI). RESULTS: Twenty studies identified 5886 patients suitable for the analysis. Physical activity showed significant improvement at 0-6 months (SMD: .50; 95% CI: .25-.76; P = .0001), >6-12 months (SMD: .58; 95% CI: .26-.91; P = .0004), and >12-36 months (SMD: .82; 95% CI: .27-1.36; P = .004) after bariatric surgery. Self-reported assessment after bariatric surgery showed significant improvement at 0-6 months (SMD: .65; 95% CI: .29-1.01; P = .0004), >6 to 12 months (SMD: .53; 95% CI: .18-.88; P = .003), and >12-36 months (SMD: .51; 95% CI: .46-.55; P < .00001). Objective assessment after bariatric surgery did not show improvement at 0-6 months (SMD: .31; 95%CI:-.05-.66; P = .09), but showed significant improvement at >6-12 months (SMD: .85; 95% CI:-.07-1.62; P = .03), and >12-36 months (SMD: 1.99; 95% CI: 1.13-2.86; P < .00001) after bariatric surgery. CONCLUSIONS: Bariatric surgery improves physical activity significantly in a population with obesity up to 3 years after surgery. Objective measurement of physical activity does not show significant improvement within 6 months of bariatric surgery but begins to improve at >6 months. Self-reported measurement of physical activity begins to show improvement within 6 months of a bariatric procedure.


Asunto(s)
Cirugía Bariátrica , Ejercicio Físico , Obesidad/psicología , Obesidad/cirugía , Humanos
16.
Postgrad Med J ; 95(1127): 470-475, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31147396

RESUMEN

BACKGROUND: The 'two-week wait'(2WW) referral pathway was introduced in the United Kingdom to reduce waiting times for treatment of cancer. There has been a debate regarding the efficacy of 2WW pathway since its implementation. METHODS: A singleinstitutional analysis of upper gastrointestinal(UGI) and lower gastrointestinal(LGI) malignancies treated between 1April 2015 and 31March 2017 was undertaken to analyse the impact of 2WWreferral pathway on the diagnosis, treatment and survival. RESULTS: 2WW referral does not achieve an earlier diagnosis compared with non-2WW routes of referral in UGI (χ2(3)=2.6, p=0.458) and LGI (χ2(3)=0.884, p=0.829) malignancies. 2WW referral does not lead to an improvement in curative treatment in UGI (OR1.48, 95%CI0.68to3.21, p=0.321) and LGI (OR1.59, 95%CI0.97to2.62, p=0.067) malignancies. No improvement in survival is seen in UGI (HR0.99, 95%CI0.56to1.75, p=0.963) and LGI (HR1.10, 95%CI0.60to1.99, p=0.764) malignancies by virtue of 2WW referral. Emergency presentation is the most common presenting route in UGI malignancy(40%) and is associated with poor survival (HR0.55, 95%CI0.30to0.97, p=0.045).Non-emergency route of presentation is associated with higher rates of curative treatment in UGI malignancies (OR3.49, 95%CI1.57to7.76, p=0.002). Lower rate of curative treatment (OR 0.27, 95%CI0.16to0.43, p<0.001) and poor survival (HR0.44, 95%CI0.26to0.76, p=0.003) is also observed in emergency presentation of LGI malignancy(29%) which is the secondmost common route of presentation in this group. CONCLUSION: 2WW referral does not achieve early diagnosis nor does it lead to an improvement in the rate of curative treatment in UGI and LGI malignancies. No improvement in short-term survival is seen in UGI malignancies nor in LGI malignancies on multivariate analysis by virtue of 2WW referral.


Asunto(s)
Neoplasias Gastrointestinales/diagnóstico , Neoplasias Gastrointestinales/terapia , Listas de Espera , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Neoplasias Gastrointestinales/mortalidad , Humanos , Masculino , Persona de Mediana Edad , Derivación y Consulta , Tasa de Supervivencia , Factores de Tiempo , Reino Unido
17.
Case Rep Gastrointest Med ; 2016: 4318015, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27957356

RESUMEN

We present a case of a seventeen-year-old patient, admitted in the care of the surgical team following inhalation of nitrous oxide at high pressure, leading to extensive pneumomediastinum and surgical emphysema. We discuss the subsequent investigations and management for this patient. In the absence of history of airway injury and respiratory problems including asthma and with no oesophageal perforation on investigations, the diagnostic and management challenges encountered have been discussed which will help in future management of similar cases.

18.
BMC Surg ; 12: 21, 2012 Oct 30.
Artículo en Inglés | MEDLINE | ID: mdl-23110681

RESUMEN

BACKGROUND: Acute mesenteric ischaemia and duodenal perforation are surgical emergencies with serious consequences. Patients presenting with acute mesenteric ischaemia alone face a high mortality rate as high as 60% whereas those presenting with peptic ulcer perforation the mortality rates range from 6-14%. There are very few reported cases of patients presenting with this dual pathology. CASE PRESENTATION: We report a unique case of a 53 year old Italian lady who presented with acute mesenteric ischaemia and duodenal perforation. This is the first report of massive bowel ischaemia and duodenal perforation with no apparent underlying common pathophysiology leading to this presentation. CONCLUSION: Early management in the intensive care unit and appropriate surgical intervention maximised the patient's chances of survival despite the poor prognosis associated with her dual pathology. The rare pathology of the patient described can be explained by two possible hypotheses: peptic ulcer disease causing duodenal ulceration, which precipitated ischaemic infarction of the small bowel. The second hypothesis is the patient developed a stress related ulcer following ischaemic bowel infarction secondary to arterial thrombosis.


Asunto(s)
Úlcera Duodenal/complicaciones , Isquemia/complicaciones , Úlcera Péptica Perforada/complicaciones , Enfermedades Vasculares/complicaciones , Femenino , Humanos , Isquemia Mesentérica , Persona de Mediana Edad
19.
World J Emerg Surg ; 7(1): 1, 2012 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-22257431

RESUMEN

The gastric fundal diverticulae are rare. They can present with variable symptoms. We are enclosing a literature review on gastric fundal diverticulum. Lessons have emerged which may help in the management of this rare condition in future.

20.
J Med Case Rep ; 5: 421, 2011 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-21878119

RESUMEN

INTRODUCTION: Unintentional ingestion of a toothpick is not an uncommon event. Often the ingested toothpicks spontaneously pass through the gut without sequelae. However, serious complications can happen when these sharp objects migrate through the gastrointestinal wall. CASE PRESENTATION: In the current report, we describe the case of a 37-year-old Caucasian woman with an incidental finding of a toothpick in the porta hepatis during laparoscopic cholecystectomy for symptomatic gall stones. CONCLUSION: Toothpick ingestion is not an uncommon event and can predispose patients to serious complications. In this particular case, the toothpick was only discovered at the time of unrelated surgery. Therefore, it was important during surgery to exclude any related or missed injury to the adjacent structures by this sharp object.

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